The as-yet unidentified male victim suffered multiple gunshot wounds and died at Ben Taub General Hospital.
Police say the crazed party attracted almost 1,000 guests and was meant to copy the popular 2012 movie.
The film chronicles the adventures of three high school students who throw an “anything goes” bash that quickly spirals out of control. So far, a series of “Project X”-inspired parties has caused over $100,000 in real-life damage and a handful of arrests.
Daniel Menjivara, a 22-year-old college student, told ABC News that “Project X” and the fact it was spring break were the reasons he decided to show up at the massive Houston bash. Menjivara said he was surprised to find that the house was full of mostly teenagers.
“The house got pretty full. You could barely move around,” he said.
The party was complete with trash cans full of spiked punch for attendees and girls who wore bathing suits were allowed in for free, according to the flyer.
Word about the party travelled fast thanks for Facebook and Twitter.
Police arrived on the scene and shut the party down around midnight.
“Kids took to the streets, but the parking lot was overpacked so you couldn’t get out,” Menjivar said. “It was just people in the actual street. They got into arguments and started shooting each other.”
Officers went after the gunman on foot but were unable to catch him.
“At this time, it has not been determined if the male pursued by officers is the suspect in this case, as it appears several people discharged weapons at the scene,” the Houston Police Department said in a statement.
Several other “Project X” copycat parties have led to arrests and thousands of dollars of damage in the Houston area alone in recent weeks.
More in the video below.